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Daimon, Takashi: Dose-Finding Designs for Early...
51,79 € *
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Erscheinungsdatum: 29.07.2019, Medium: Taschenbuch, Einband: Kartoniert / Broschiert, Titel: Dose-Finding Designs for Early-Phase Cancer Clinical Trials, Titelzusatz: A Brief Guidebook to Theory and Practice, Autor: Daimon, Takashi // Hirakawa, Akihiro // Matsui, Shigeyuki, Verlag: Springer-Verlag GmbH // Springer Tokyo, Sprache: Englisch, Schlagworte: Biostatistik // Statistik // Epidemiologie // Mathematik // Stochastik // Wahrscheinlichkeitsrechnung // Biowissenschaften // Life Sciences // MEDICAL // Biostatistics // Epidemiologie und medizinische Statistik // Wahrscheinlichkeitsrechnung und Statistik // allgemein, Rubrik: Medizin // Allgemeines, Lexika, Seiten: 133, Abbildungen: Bibliographie, Reihe: SpringerBriefs in Statistics, Informationen: Book, Gewicht: 251 gr, Verkäufer: averdo

Anbieter: averdo
Stand: 26.02.2020
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Hepatobiliary and Pancreatic Carcinogenesis in ...
192,59 € *
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Malignant neoplasms occurring in the biliary tract and pancreas remain a therap- tic challenge. The mechanism of carcinogenesis as well as the growth and spread of these tumors is still poorly understood, making the development of rational tre- ment strategies difficult. In order to improve the clinical results achieved by sur- cal or other medical treatment of such malignant tumors, the establishment of an experimental animal model is critical. For this purpose, attempts were made to induce carcinoma experimentally in the biliary tree and finally an animal model using the hamster was established in 1994 at our laboratory. Because the tumor in this model mimicked the characteristics of human tumors, a series of experimental investigations were conducted to clarify the pathological characteristics of biliary carcinoma, the genetic alterations during biliary carcinogenesis, and the relationship between biliary inflammation and c- cinogenesis. The chemopreventive effects on the occurrence of biliary carcinoma were also successfully examined. In addition, in vitro studies led to the establi- ment of transplantable biliary cancer cell lines and biliary epithelial cell lines by utilizing the hamster model. This monograph represents the collective efforts in hepato-biliary and pancreatic disease research over the past 20 years. I hope that this monograph will be a source of useful knowledge for basic researchers as well as for clinicians involved in the care of patients with hepato-biliary and pancreatic neoplasms. Takashi Kanematsu, M.D., Ph.D.

Anbieter: Dodax
Stand: 26.02.2020
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Handbook of Japanese Applied Linguistics
310,00 € *
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Applied linguistics is the best single label to represent a wide range of contemporary research at the intersection of linguistics, anthropology, psychology, and sociology, to name a few. The Handbook of Japanese Applied Linguistics reflects crosscurrents in applied linguistics, an ever-developing branch/discipline of linguistics. The book is divided into seven sections, where each chapter discusses in depth the importance of particular topics, presenting not only new findings in Japanese, but also practical implications for other languages. Section 1 examines first language acquisition/development, whereas Section 2 covers issues related to second language acquisition/development and bilingualism/multilingualism. Section 3 presents problems associated with the teaching and learning of foreign languages. Section 4 undertakes questions in corpus/computational linguistics. Section 5 deals with clinical linguistics, and Section 6 takes up concerns in the area of translation/interpretation. Finally, Section 7 discusses Japanese sign language. Covering a wide range of current issues in an in an in-depth, comprehensive manner, the book will be useful for researchers as well as graduate students who are interested in Japanese linguistics in general, and applied linguistics in particular. Chapter titles Chapter 1. Cognitive Bases and Caregivers' Speech in Early Language Development (Tamiko Ogura, Tezukayama University)Chapter 2. Literacy Acquisition in Japanese Children (Etsuko Haryu, University of Tokyo)Chapter 3. Age Factors in Language Acquisition (Yuko Goto Butler, University of Pennsylvania)Chapter 4. Cross-lingual Transfer from L1 to L2 Among School-age Children (Kazuko Nakajima, University of Toronto)Chapter 5. Errors and Learning Strategies by Learners of Japanese as an L2 (Kumiko Sakoda, Hiroshima University/NINJAL)Chapter 6. Adult JFL Learners' Acquisition of Speech Style Shift (Haruko Minegishi Cook, University of Hawai'i at Manoa)Chapter 7. Japanese Language Proficiency Assessment (Noriko Kobayashi, Tsukuba University)Chapter 8. The Role of Instruction in Acquiring Japanese as a Second Language (Kaoru Koyanagi, Sophia University)Chapter 9. The Influence of Topic Choice on Narrative Proficiency by Learners of Japanese as a Foreign Language (Masahiko Minami, San Francisco State University)Chapter 10. CHILDES for Japanese: Corpora, Programs, and Perspectives (Susanne Miyata, Aichi Shukutoku University)Chapter 11. KY Corpus (Jae-Ho Lee, Tsukuba University)Chapter 12. Corpus-based Second Language Acquisition Research (Hiromi Ozeki, Reitaku University)Chapter 13. Assessment of Language Development in Children with Hearing Impairment and Language Disorders (Kiyoshi Otomo, Tokyo Gakugei University)Chapter 14. Speech and Language Acquisition in Japanese Children with Down Syndrome (Toru Watamaki, Nagasaki University)Chapter 15. Revisiting Autistic Language: Is "literalness" a Truth or Myth? Manabu Oi (Osaka University/Kanazawa University)Chapter 16. Towards a Robust, Genre-based Translation Model and its Application (Judy Noguchi, Mukogawa Women's University, Atsuko Misaki, Kwansei Gakuin University, Shoji Miyanaga, Ritsumeikan University, Masako Terui, Kinki University)Chapter 17. Japanese Sign Language: An Introduction (Daisuke Hara, Toyota Technological Institute)Chapter 18. Japanese Sign Language Phonology and Morphology (Daisuke Hara, Toyota Technological Institute)Chapter 19. Japanese Sign Language Syntax (Noriko Imazato, Kobe City College of Technology)Chapter 20. Sign Language Development and Language Input (Takashi Torigoe, Hyogo University of Teacher Education)

Anbieter: Dodax
Stand: 26.02.2020
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Hepatobiliary and Pancreatic Carcinogenesis in ...
255,00 CHF *
ggf. zzgl. Versand

Malignant neoplasms occurring in the biliary tract and pancreas remain a therap- tic challenge. The mechanism of carcinogenesis as well as the growth and spread of these tumors is still poorly understood, making the development of rational tre- ment strategies difficult. In order to improve the clinical results achieved by sur- cal or other medical treatment of such malignant tumors, the establishment of an experimental animal model is critical. For this purpose, attempts were made to induce carcinoma experimentally in the biliary tree and finally an animal model using the hamster was established in 1994 at our laboratory. Because the tumor in this model mimicked the characteristics of human tumors, a series of experimental investigations were conducted to clarify the pathological characteristics of biliary carcinoma, the genetic alterations during biliary carcinogenesis, and the relationship between biliary inflammation and c- cinogenesis. The chemopreventive effects on the occurrence of biliary carcinoma were also successfully examined. In addition, in vitro studies led to the establi- ment of transplantable biliary cancer cell lines and biliary epithelial cell lines by utilizing the hamster model. This monograph represents the collective efforts in hepato-biliary and pancreatic disease research over the past 20 years. I hope that this monograph will be a source of useful knowledge for basic researchers as well as for clinicians involved in the care of patients with hepato-biliary and pancreatic neoplasms. Takashi Kanematsu, M.D., Ph.D.

Anbieter: Orell Fuessli CH
Stand: 26.02.2020
Zum Angebot
Hepatobiliary and Pancreatic Carcinogenesis in ...
186,99 € *
ggf. zzgl. Versand

Malignant neoplasms occurring in the biliary tract and pancreas remain a therap- tic challenge. The mechanism of carcinogenesis as well as the growth and spread of these tumors is still poorly understood, making the development of rational tre- ment strategies difficult. In order to improve the clinical results achieved by sur- cal or other medical treatment of such malignant tumors, the establishment of an experimental animal model is critical. For this purpose, attempts were made to induce carcinoma experimentally in the biliary tree and finally an animal model using the hamster was established in 1994 at our laboratory. Because the tumor in this model mimicked the characteristics of human tumors, a series of experimental investigations were conducted to clarify the pathological characteristics of biliary carcinoma, the genetic alterations during biliary carcinogenesis, and the relationship between biliary inflammation and c- cinogenesis. The chemopreventive effects on the occurrence of biliary carcinoma were also successfully examined. In addition, in vitro studies led to the establi- ment of transplantable biliary cancer cell lines and biliary epithelial cell lines by utilizing the hamster model. This monograph represents the collective efforts in hepato-biliary and pancreatic disease research over the past 20 years. I hope that this monograph will be a source of useful knowledge for basic researchers as well as for clinicians involved in the care of patients with hepato-biliary and pancreatic neoplasms. Takashi Kanematsu, M.D., Ph.D.

Anbieter: Thalia AT
Stand: 26.02.2020
Zum Angebot